COMBINATION TREATMENTS OF CHINESE-HAMSTER OVARY CELLS WITH VARIOUS RESTRICTION ENDONUCLEASES RESULT IN CHROMOSOMAL-ABERRATIONS WHOSE FREQUENCIES ARE ADDITIVE OR LESS-THAN ADDITIVE

Authors
JOHANNES C OBE G
Citation
C. Johannes et G. Obe, COMBINATION TREATMENTS OF CHINESE-HAMSTER OVARY CELLS WITH VARIOUS RESTRICTION ENDONUCLEASES RESULT IN CHROMOSOMAL-ABERRATIONS WHOSE FREQUENCIES ARE ADDITIVE OR LESS-THAN ADDITIVE, Mutation research, 309(2), 1994, pp. 211-217
Citations number
7
Categorie Soggetti
Genetics & Heredity",Biology
Journal title
Mutation research → ACNP
ISSN journal
00275107
Volume
309
Issue
2
Year of publication
1994
Pages
211 - 217
Database
ISI
SICI code
0027-5107(1994)309:2<211:CTOCOC>2.0.ZU;2-2
Abstract
Chinese hamster ovary cells were treated with combinations of differen t restriction endonucleases (RE). The frequencies of chromosomal aberr ations after combination treatments were additive or less than additiv e when compared with the effects of the single RE. These data indicate that DNA double-strand breaks (DSB) induced by different types of RE in combination treatments lead to chromosomal aberrations in the same way as DSB induced by single RE.