Spontaneous intracranial bleeding in two patients with congenital afibrinogenaemia and the role of replacement therapy

Authors
Parameswaran, R Dickinson, JP De Lord, S Keeling, DM Colvin, BT
Citation
R. Parameswaran et al., Spontaneous intracranial bleeding in two patients with congenital afibrinogenaemia and the role of replacement therapy, HAEMOPHILIA, 6(6), 2000, pp. 705-708
Citations number
9
Categorie Soggetti
Hematology
Journal title
HAEMOPHILIA
ISSN journal
13518216 → ACNP
Volume
6
Issue
6
Year of publication
2000
Pages
705 - 708
Database
ISI
SICI code
1351-8216(200011)6:6<705:SIBITP>2.0.ZU;2-N
Abstract
Congenital afibrinogenaemia and hypofibrinogenaemia are rare disorders of h aemostasis. In this case report the problems posed in the management of two patients with fibrinogen levels less than 0.1 g L-1 and who developed intr acranial bleeding are considered. The value of fibrinogen concentrate and t he role of prophylaxis is also discussed.