Tyrolobibenzyls - Novel secondary metabolites from Scorzonera humilis

Authors
Zidorn, C Ellmerer-Muller, EP Stuppner, H
Citation
C. Zidorn et al., Tyrolobibenzyls - Novel secondary metabolites from Scorzonera humilis, HELV CHIM A, 83(11), 2000, pp. 2920-2925
Citations number
11
Categorie Soggetti
Chemistry & Analysis",Chemistry
Journal title
HELVETICA CHIMICA ACTA
ISSN journal
0018019X → ACNP
Volume
83
Issue
11
Year of publication
2000
Pages
2920 - 2925
Database
ISI
SICI code
0018-019X(2000)83:11<2920:T-NSMF>2.0.ZU;2-J
Abstract
Tyrolobibenzyls A (2), B (3), and C (4) were isolated from Scorzonera humil is (Asteraceae) of Tyrolean origin. Compounds 2 and 3 possess a unique phen ylethyl-benzofuran backbone and represent a new class of natural compounds. Structural assignments are based on 1D and 2D NMR as well as MS data. Furt hermore. peracetylated derivatives of compounds 3 and 4 were synthesized. P harmacological evaluation of these compounds by the [H-3]thymidine assay sh owed no pronounced cytotoxicity.