Syntheses of new racemic N-G-(1-lminoethyl)phosphalysine derivatives as potential inhibitors of nitric oxide synthase

Authors
Massa, MA Pitzele, BS Jerome, GM Moore, WM Manning, PT Sikorski, JA
Citation
Ma. Massa et al., Syntheses of new racemic N-G-(1-lminoethyl)phosphalysine derivatives as potential inhibitors of nitric oxide synthase, HETEROAT CH, 11(7), 2000, pp. 505-511
Citations number
25
Categorie Soggetti
Chemistry
Journal title
HETEROATOM CHEMISTRY
ISSN journal
10427163 → ACNP
Volume
11
Issue
7
Year of publication
2000
Pages
505 - 511
Database
ISI
SICI code
1042-7163(2000)11:7<505:SONRND>2.0.ZU;2-I
Abstract
The efficient syntheses of three Mew racemic N-G-(1-iminoethyl)phosphalysin e derivatives are reported where the lysine carboxylate group is systematic ally replaced by phosphonic acid, 4, methyl phosphinic acid, 5, and phosphi nic acid, 6. These compounds were evaluated as potential inhibitors of the three isoforms of human nitric oxide synthase. (C) 2000 John Wiley & Sons, Inc.