A facile asymmetric synthesis of 1-amino 2,2,2-trifluoroethanephosphonic acid

Starting from the fundamental building block, trifluoromethylated N-(-)-alp ha -methylbenzylacetimidoyl chloride, an asymmetric synthesis of 1-amino-2, 2,2-trifluoroethanephosphonic acid was conveniently achieved by a base-cata lyzed [1,3]-proton shift reaction of the intermediate dialkyl 1-imino-2,2,2 -trifluoroethanephosphonate. (C) 2000 John Wiley & Sons, Inc.