Genotyping in HIV drug resistance mutations: epidemiology in 145 patients

The epidemiology of HIV-1 genomic mutations causing antiretroviral drug res istance, in 145 HIV-1 infected patients were obtained using a new sequencin g technique. All patients were in a follow up treatment for at least 4 mont hs with all drugs available in clinical practice in accordance to internati onal guidelines. The percentage of the mutations were calculated both on th e number of all participants and on the number of patients who received the drugs selecting for that specific resistance. It was possible then to eval uate patients who showed the mutation without receiving the drug. We consid er this new sequencing method reliable and hopeful in clinical practice, gi ving the opportunity for a guided therapy for the single patient and in det ecting and monitoring the antiretroviral drug resistance mutations in the p ertinent geographic area following a periodic surveillance program. (C) 200 0 Elsevier Science B.V. and International Society of Chemotherapy. All righ ts reserved.