The delivery of protein into living cells by use of membrane fusible erythrocyte ghosts

Authors
Kogure, K Itoh, T Okuda, O Hayashi, K Ueno, M
Citation
K. Kogure et al., The delivery of protein into living cells by use of membrane fusible erythrocyte ghosts, INT J PHARM, 210(1-2), 2000, pp. 117-120
Citations number
4
Categorie Soggetti
Pharmacology & Toxicology
Journal title
INTERNATIONAL JOURNAL OF PHARMACEUTICS
ISSN journal
03785173 → ACNP
Volume
210
Issue
1-2
Year of publication
2000
Pages
117 - 120
Database
ISI
SICI code
0378-5173(200012)210:1-2<117:TDOPIL>2.0.ZU;2-W
Abstract
We examined the effects of pretreatment of monkey kidney normal cells (CV-1 ) and human cervical tumor cells (HeLa) with membrane fusible erythrocyte g hosts (MFEG) encapsulating superoxide dismutase (SOD-MFEG) on adriamycin (A DM) cytotoxicity. The decrease in CV-1 cells with ADM was inhibited markedl y, and the initiation of decrease in HeLa cells was delayed for 2 days by t he pretreatment with SOD-MFEG, indicating that the delivered SOD held the a ctivity in the cells. (C) 2000 Elsevier Science B.V. All rights reserved.