Long-term pulmonary insufficiency resulting from simple transannular patchi
ng of the right ventricle outflow tract will ultimately lead to deteriorati
on in right ventricular function. Previously, monocusps constructed from xe
nografts, homografts, fascia lata, and autologous pulmonary artery wall hav
e been utilized to minimize pulmonary regurgitation and its deleterious eff
ect on right ventricular function. However, these tend to degenerate in the
long term, necessitating reoperation. To circumvent this problem we have u
sed a monocusps constructed from 0.1-mm polytetrafluorethylene (PTFE, peric
ardial membrane) clinically demonstrated to be resistant to issue ingrowth
and degeneration. Seven children (5 tetralogy of Fallot, 2 pulmonary stenos
is) who required division of a small pulmonary annulus underwent monocusp c
onstruction with 0.1-mm PTFE. Three patients had previous corrective surger
y. One of these patients had a bovine pericardial monocusp placed 8 years p
reviously, which degenerated. Of the remaining two patients, one had a pulm
onary valvotomy as a neonate, the other repair of tetralogy of Fallot with
a transannular patch. At a mean (+/- standard deviation) follow up to 17 +/
- 5.8 months all patients are alive and are New York Heart Association (NYH
A) Class I. Echocardiography demonstrates mild pulmonary insufficiency (PI)
in 2 patients, mild to moderate PI in 4, and moderate to severe PI in 1. T
he presence of a pericardial membrane monocusp in the pulmonary position ma
y, in the long term, prevent the deleterious effects of transannular patchi
ng on right ventricular dysfunction and be more resistant to degenerative c
hanges characteristic of monocusps constructed of native pericardium or all
ogeneic tissue.