Complete androgen insensitivity syndrome: Long-term medical, surgical, andpsychosexual outcome

Controversy concerning the most appropriate treatment guidelines for inters ex children currently exists. This is due to a lack of long-term informatio n regarding medical, surgical, and psychosexual outcome in affected adults. We have assessed by questionnaire and medical examination the:physical and psychosexual status of 14 women with documented complete androgen insensit ivity syndrome (CAIS). We have also determined participant knowledge of CAI S as well as opinion of medical and surgical treatment. As a whole, seconda ry sexual development of these women was satisfactory, as judged by both pa rticipants and physicians. In general, most women were satisfied with their psychosexual development and sexual function. Factors reported to contribu te to dissatisfaction were sexual abuse in one case and marked obesity in a nother. All of the women who participated were satisfied with having been r aised as females, and none desired a gender reassignment. Although not perf ect, the medical, surgical, and psychosexual outcomes for women with CAIS w ere satisfactory; however, specific ways for improving long-term treatment of this population were identified.