Hormonal regulation of radioiodide uptake activity and Na+/I- symporter expression in mammary glands

Citation
Jy. Cho et al., Hormonal regulation of radioiodide uptake activity and Na+/I- symporter expression in mammary glands, J CLIN END, 85(8), 2000, pp. 2936-2943
Citations number
28
Categorie Soggetti
Endocrynology, Metabolism & Nutrition","Endocrinology, Nutrition & Metabolism
Journal title
JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM
ISSN journal
0021972X → ACNP
Volume
85
Issue
8
Year of publication
2000
Pages
2936 - 2943
Database
ISI
SICI code
0021-972X(200008)85:8<2936:HRORUA>2.0.ZU;2-F
Abstract
The observation that radioiodide uptake (RAIU) activity, mediated by the Na +/I- symporter (NIS), is significantly increased in lactating breast sugges ts that RAIU and NIS expression in mammary gland are modulated by hormones involved in active lactation. We showed that both the NIS expression level and RAIU in rat mammary gland are maximal during active lactation compared to those in the mammary glands of virgin and pregnant rats as well as the i nvoluting mammary gland. In the lactating mammary gland, NIS is clustered o n the basolateral membrane of alveolar cells as a lesser glycosylated form than NIS in thyroid. The RAIU of lactating mammary gland was partially inhi bited by treatment with a selective oxytocin antagonist or bromocriptine, a n inhibitor of PRL release. These findings suggest that RAIU and NIS expres sion in mammary gland are at least in part modulated by oxytocin and PRL. I ndeed, we showed that NIS messenger ribonucleic acid level was increased in a dose-dependent manner by oxytocin and PRL in histocultured human breast tumors.