ROLE OF CHLOROPHYLLIN AS AN IN-VIVO ANTICLASTOGEN - PROTECTION AGAINST GAMMA-RADIATION AND CHEMICAL CLASTOGENS

Chlorophyllin was evaluated in the mouse bone marrow micronucleus test for its possible protective effects against chromosomal damage induce d by gamma-radiation, cyclophosphamide, N-nitroso-N-ethylurea and uret hane. Three doses of chlorophyllin (50, 100 and 200 mg/kg, b.w.) were orally administered to mice 2 h before exposure to the clastogens unde r investigation. The results obtained demonstrated that chlorophyllin can significantly reduce the incidence of micronucleated polychromatic erythrocytes induced by gamma-radiation (1.15 Gy) and all the three c hemical clastogens. However with the exception of cyclophosphamide the re was no indication of a dose response for the in vivo anticlastogeni c effects of chlorophyllin.