Determination of tricyclic antidepressants using a carbon paste electrode modified with beta-cyclodextrin

Citation
A. Ferancova et al., Determination of tricyclic antidepressants using a carbon paste electrode modified with beta-cyclodextrin, J ELEC CHEM, 492(1), 2000, pp. 74-77
Citations number
8
Categorie Soggetti
Spectroscopy /Instrumentation/Analytical Sciences
Journal title
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
ISSN journal
15726657 → ACNP
Volume
492
Issue
1
Year of publication
2000
Pages
74 - 77
Database
ISI
SICI code
Abstract
Carbon paste electrodes modified with beta -cyclodextrin have been investig ated for the DP voltammetric determination of the tricyclic antidepressants - imipramine, trimipramine and thioridazine. Host-guest interaction was st udied and experimental conditions of the working procedure were optimized. The accumulation ability of beta -cyclodextrin leads to detection limits do wn to nanomolar concentrations for 120 s accumulation. The electrode was ap plied to the determination of imipramine and thioridazine in pharmaceutical s. (C) 2000 Elsevier Science B.V. All rights resented.