Determination of tricyclic antidepressants using a carbon paste electrode modified with beta-cyclodextrin

Carbon paste electrodes modified with beta -cyclodextrin have been investig ated for the DP voltammetric determination of the tricyclic antidepressants - imipramine, trimipramine and thioridazine. Host-guest interaction was st udied and experimental conditions of the working procedure were optimized. The accumulation ability of beta -cyclodextrin leads to detection limits do wn to nanomolar concentrations for 120 s accumulation. The electrode was ap plied to the determination of imipramine and thioridazine in pharmaceutical s. (C) 2000 Elsevier Science B.V. All rights resented.