Lipoprotein lipase (C/G)(447) polymorphism and blood pressure in the Stanislas Cohort

Objective Association between blood pressure and triglyceride levels, and b etween lipoprotein lipase (LPL) (C/G)(447) polymorphism and triglyceride le vels has been described, We investigated whether the LPL (C/G)447 polymorph ism was associated with blood pressure (BP) revels and longitudinal changes , Design and participants For cross-sectional analysis, 767 men and 816 women (29-55 years) were selected from the Stanislas Cohort, a cohort of volunte ers for a free health check-up, Only subjects without anti-hypertensive or lipid-lowering medication were included in the study. A subset of this samp le population, 359 men and 337 women, had been followed during the 11 years prior to recruitment in the Stanislas Cohort and was used for longitudinal analysis. Results The cross-sectional study showed that serum triglyceride levels dif fered significantly according to LPL genotypes in both genders, the G447 al lele being associated with the lowest triglyceride levels (P less than or e qual to 0.01), Univariate and multivariate analysis found that LPL polymorp hism was not related to BP levels in men. In contrast, women with the LPL-G 447 allele had lower systolic (SBP) and pulse (PP) pressure levels than tho se with the LPL-CC genotype (P less than or equal to 0.01 and P less than o r equal to 0.05, respectively); this association being independent of trigl yceride level, The longitudinal study showed LPL genotype was an independen t predictor of PP and SEP follow-up levels in women; changes over 11 years being lower for LPL-G447 allele carriers (P less than or equal to 0.05), Th ese associations were independent of triglyceride level, Conclusion The LPL-G447 allele was found associated with lower PP and SEP i ndependently of triglyceride revel in women. This result suggests that the LPL gene may influence blood pressure, (C) 2000 Lippincott Williams & Wilki ns.