Gamma knife radiosurgery for pituitary adenomas

Object. The purpose of this study was the analysis of a large series of pat ients treated with gamma knife radiosurgery for pituitary adenoma in a sing le institution. Methods. One hundred eight patients with pituitary adenomas were treated ov er the last 7 years. Seventy-four patients have been followed for more than 6 months and form the basis of this report. Conclusions. Twenty-three patients harbored nonfunctioning adenomas, and 56 harbored functioning adenomas. The mean margin dose was 22.5 Gy (nonfuncti oning adenomas, 19.5 Gy; functioning adenomas, 23.8 Gy). Control of tumor g rowth was achieved in 91%. A significant decrease of excessive hormone prod uction was seen in 80% of patients, and the endocrinological normalization rate was 30.3%. Postradiosurgical complications were seen in 2.5%.