An azygos pericallosal artery (APCA) aneurysm is a rare anomaly that is clo
sely associated with saccular aneurysms. This is the earliest report to doc
ument de novo formation and rupture of an aneurysm at the bifurcation of an
unpaired pericallosal trunk. The authors report the case of a woman who pr
esented at the age of 52 years with subarachnoid hemorrhage (SAH) from the
rupture of a newly formed APCA bifurcation aneurysm, 7 years after she had
undergone surgery to clip a ruptured anterior cerebral artery aneurysm. De
novo formation of aneurysms after SAH rarely occurs and certain risk factor
s like multiple and familial aneurysms, arterial hypertension, or smoking h
ave been postulated. Late follow-up examination with angiography to detect
de novo aneurysms should be considered in patients with this vascular anoma
ly after SAH.