Studies of personality and problem behaviors may begin with analyses of the
problem and develop hypotheses about personality traits that might be rele
vant; or they may begin with models of personality and explore links to beh
avior. Because it is well validated and relatively comprehensive, the Five-
Factor Model (FFM) of personality lends itself to systematic exploratory st
udies that may sometimes lead to unanticipated findings. In this article, w
e review a program of research in a high-risk, disadvantaged population tha
t illustrates the utility of the FFM in understanding health risk behavior.
Previous analyses showed that behavior associated with the risk of HIV inf
ection can be predicted from the personality dispositions of Neuroticism an
d (low) Conscientiousness.