Cutaneous manifestations of end-stage renal disease

Examination of the skin and nails dan reveal many abnormalities in patients with end-stage renal disease that precede or follow initiation of dialysis treatment or kidney transplantation. This article focuses on specific and nonspecific cutaneous signs of end-stage renal disease, reviewing both bana l and life-threatening conditions, including pruritus, perforating disorder s, calcifying disorders, and bullous dermatoses. The pathogenesis, clinical findings, histologic findings, differential diagnosis, and treatment of th ese diseases are discussed. Cutaneous manifestations unique to kidney trans plantation will not be covered.