A zinc thiolate species which mimics aspects of the chemistry of the Ada repair protein and matrix metalloproteinases: the synthesis, structure and reactivity of the tris(2-mercapto-1-phenylimidazolyl)hydroborato complex [Tm-Ph]ZnSPh

Authors
Bridgewater, BM Fillebeen, T Friesner, RA Parkin, G
Citation
Bm. Bridgewater et al., A zinc thiolate species which mimics aspects of the chemistry of the Ada repair protein and matrix metalloproteinases: the synthesis, structure and reactivity of the tris(2-mercapto-1-phenylimidazolyl)hydroborato complex [Tm-Ph]ZnSPh, J CHEM S DA, (24), 2000, pp. 4494-4496
Citations number
33
Categorie Soggetti
Inorganic & Nuclear Chemistry
Journal title
JOURNAL OF THE CHEMICAL SOCIETY-DALTON TRANSACTIONS
ISSN journal
14727773 → ACNP
Issue
24
Year of publication
2000
Pages
4494 - 4496
Database
ISI
SICI code
1472-7773(2000):24<4494:AZTSWM>2.0.ZU;2-3
Abstract
The tris(2-mercapto-1-phenylimidazolyl)hydroborato ligand, [Tm-Ph], has bee n used to prepare the zinc phenylthiolate derivative, [Tm-Ph]ZnSPh, which p rovides a good structural model for zinc enzymes that possess [Zn(Cys)(4)] motifs; furthermore, the reactivity of the thiolate linkage in [Tm-Ph]ZnSPh mimics the chemistry of the Ada protein and the activation mechanism of ma trix metalloproteinases.