Lipid peroxidation in rat adrenal glands after administration cadmium and role of essential metals

The aim of this study was to investigate the effects of cadmium-induced per oxidative damage to rat adrenals. Cadmium significantly increased adrenal l ipid peroxidation in a dose- and time-related manner. Cadmium-induced lipid peroxidation was accompanied by a marked elevation in adrenal iron (Fe) le vels, in particular the free elemental form. Chelation of Fe with deferoxam ine decreased the cadmium effect on lipid peroxidation. Selenium (Se) was a lso effective in inhibiting Cd-induced adrenal lipid peroxidation. Data ind icate that Cd-induced lipid peroxidation in rat adrenals may be dependent u pon Fe and Se levels in this tissue.