Ml. Blute et al., Use of Gleason score, prostate specific antigen, seminal vesicle and margin status to predict biochemical failure after radical prostatectomy, J UROL, 165(1), 2001, pp. 119-125
Purpose: We determine the importance of clinical and pathological variables
for predicting biochemical progression in patients after surgery for speci
men confined prostate cancer. We developed a simple scoring algorithm for b
iochemical progression in node negative cases and tested the algorithm perf
ormance on an independent group.
Materials and Methods: Our study included 2,518 patients with pTSN0 or pT3N
0 disease treated between 1990 and 1993. Gleason score, preoperative prosta
te specific antigen (PSA), margin status, extraprostatic extension, seminal
vesicle involvement, DNA ploidy and adjuvant treatment were primary variab
les analyzed univariately. The Cox proportional hazards model was used on 2
,000 randomly selected patients to develop a multivariate scoring algorithm
for the aforementioned factors to predict biochemical progression-free sur
vival. The final model included Gleason score, preoperative PSA, margin sta
tus, seminal vesicle involvement and adjuvant treatment. The prognostic sco
re derived from this model was validated by applying it to the remaining 51
8 patients. Harrell's measure of concordance (C) was used to compare compet
ing models.
Results: For patients who did not receive adjuvant therapy the derived scor
e based on the Cox model coefficient was Gleason +1 (PSA 4 to 10), +2 (PSA
10.1 to 20), +3 (PSA greater than 20), +2 (positive seminal vesicle) and +2
(positive margin). The score was reduced by 4 if adjuvant hormonal therapy
was given and by 2 for only adjuvant radiotherapy. The 5-year progression-
free survival was 94% for scores less than 5, 60% for 10 and 32% for greate
r than 12 (C = 0.718). Applying the score to the independent validation dat
a set (518) resulted in 5-year progression-free survival of 96% for scores
less than 5, 53% for 10 and 30% for greater than 12 (C = 0.759).
Conclusions: Progression-free survival determined by the model score group
identified a wide range of risk levels for patients with specimen confined
prostate cancer. This simple predictive model allows identification of pati
ents at high risk for cancer progression with specimen confined disease who
may be targeted for closer surveillance and adjuvant therapy, while those
at lower risk may be simply observed.