D. Urban et al., The effect of isolated soy protein on plasma biomarkers in elderly men with elevated serum prostate specific antigen, J UROL, 165(1), 2001, pp. 294-300
Purpose: We performed a randomized double-blind crossover pilot study in el
derly men with elevated prostate specific antigen (PSA) on the effects of t
he daily consumption of 2 soy beverages, each containing 20 gm. of isolated
soy protein, on the isoflavone concentration in blood and urine, and on th
e 3 serum biomarkers cholesterol, PSA and the soluble p105 component of the
p185erbB-2 proto-oncogene.
Materials and Methods: A total of 34 men supplemented their diet by consumi
ng 1 of 2 soy protein beverages assigned randomly twice daily for a 6-week
period. In a second 6-week period they consumed the other soy protein bever
age. The beverage ISP+ provided 42 mg. of genistein and 27 mg. of daidzein
daily, whereas the other beverage, ISP-, provided only 2.1 and 1.3 mg. of t
hese isoflavones daily, respectively. Blood and 24-hour urine samples were
obtained before the study, at 2-week intervals during the study and 2 weeks
after study completion.
Results: ISP+ and to a lesser extent ISP- substantially increased the serum
concentration and urinary output of the isoflavones and their metabolites.
Serum cholesterol was significantly decreased by ISP+ irrespective of the
order in which the 2 soy beverages were administered and in apparent correl
ation with the total isoflavone concentration. There was no significant eff
ect of the soy beverages on serum PSA and p105erbB-2 values.
Conclusions: This study reveals that short-term exposure of elderly men wit
h elevated serum PSA values to soy protein containing isoflavones decreases
serum cholesterol but not the serum biomarkers PSA and p105erbB-2.