RHINOCEREBRAL MUCORMYCOSIS - EVOLUTION OF THE DISEASE AND TREATMENT OPTIONS

Rhinocerebral mucormycosis is recognized as a potentially aggressive a nd commonly fatal fungal infection. The classic presentation is involv ement of nasal mucosa with invasion of the paranasal sinuses and orbit . Mucormycosis is most commonly seen in association with diabetic keto acidosis, but disease demographics have changed with the onset of AIDS and the advent of powerful immunosuppressive drugs. Treatment include s aggressive debridement, systemic antifungal therapy, and control of underlying comorbid factors. Although surgical intervention remains es sential, advances in medical therapy have permitted a more limited sur gical approach to minimize functional loss without compromising surviv al. We present the UCLA experience with rhinocerebral mucormycosis fro m 1955 to 1995, with emphasis on the evolution of disease presentation and alternative treatment options.