Developmental seizures induced by common early-life insults: Short- and long-term effects on seizure susceptibility

Authors
Jensen, FE Baram, TZ
Citation
Fe. Jensen et Tz. Baram, Developmental seizures induced by common early-life insults: Short- and long-term effects on seizure susceptibility, MENT RET D, 6(4), 2000, pp. 253-257
Citations number
62
Categorie Soggetti
Pediatrics
Journal title
MENTAL RETARDATION AND DEVELOPMENTAL DISABILITIES RESEARCH REVIEWS
ISSN journal
10804013 → ACNP
Volume
6
Issue
4
Year of publication
2000
Pages
253 - 257
Database
ISI
SICI code
1080-4013(2000)6:4<253:DSIBCE>2.0.ZU;2-A
Abstract
The immature brain is highly susceptible to seizures induced by a variety o f insults, including hypoxia, fever, and trauma. Unlike early life epilepsy associated with congenital dysplasias or genetic abnormalities, insults in duce a hyperexcitable state in a previously normal brain. Here we evaluate the epileptogenic effects of seizure-inducing stimuli on the developing bra in, and the age and regional specificity of these effects. (C) 2000 Wiley-L iss. Inc.