Diagnosis of defects in the type 1 cytokine pathway

Authors
Lammas, DA Drysdale, P Ben-Smith, A Girdlestone, J Edgar, D Kumararatne, DS
Citation
Da. Lammas et al., Diagnosis of defects in the type 1 cytokine pathway, MICROBES IN, 2(13), 2000, pp. 1567-1578
Citations number
29
Categorie Soggetti
Immunology
Journal title
MICROBES AND INFECTION
ISSN journal
12864579 → ACNP
Volume
2
Issue
13
Year of publication
2000
Pages
1567 - 1578
Database
ISI
SICI code
1286-4579(200011)2:13<1567:DODITT>2.0.ZU;2-O
Abstract
Patients with inherited defects in the interleukin-12 (IL-12)-dependent, 'h igh-output' interferon-gamma (IFN-gamma) pathway exhibit selective suscepti bility to poorly pathogenic mycobacterial and salmonella infections. This r eview summarises the extended clinical spectrum seen in this group of patie nts and indicates a strategy for the identification of putative defects in the type 1 cytokine pathway. (C) 2000 Editions scientifiques et medicales E lsevier SAS.