Susceptibility and resistance to Trypanosoma congolense infections

We have put emphasis on recent findings in experimental Trypanosoma congole nse infections in highly susceptible BALB/c and relatively resistant C57B1/ 6 mice. Based on various analyses, it has been shown that a major differenc e in resistance to T. congolense infections is expressed early in infection at the macrophage level. A novel plastic-adherent Thy1.2(+) suppressor lym phocyte, which in absolute synergy with a Thy 1.2(-) cell exerts its suppre ssion via interleukin-10 and interferon-gamma opens up an exciting new fiel d of research. (C) 2000 Editions scientifiques et medicales Elsevier SAS.