Reciprocal regulation of polarized cytokine production by effector B and Tcells

Although B cells produce cytokines it is not known whether B cells can diff erentiate into effector subsets that secrete polarized arrays of cytokines. We have identified two populations of "effector" B cells (Bel and Be2) tha t produce distinct patterns of cytokines depending on the cytokine environm ent in which the cells were stimulated during their primary encounter with antigen and T cells. These effector B cell subsets subsequently regulate th e differentiation of naive CD4(+)T cells to T(H)1 and T(H)2 cells through p roduction of polarizing cytokines such as interleukin 4 and interferon gamm a. In addition, Eel and Be2 cells could, be identified in animals that were infected with pathogens that preferentially induce a Type I or Type 2 immu ne response. Together these results suggest that, in addition to their well defined role in antibody production, B cells may regulate immune responses to infectious pathogens through their production of cytokines.