Latent Mycobacterium tuberculosis - persistence, patience, and winning by waiting

Authors
Manabe, YC Bishai, WR
Citation
Yc. Manabe et Wr. Bishai, Latent Mycobacterium tuberculosis - persistence, patience, and winning by waiting, NAT MED, 6(12), 2000, pp. 1327-1329
Citations number
25
Categorie Soggetti
Research/Laboratory Medicine & Medical Tecnology","Medical Research General Topics
Journal title
NATURE MEDICINE
ISSN journal
10788956 → ACNP
Volume
6
Issue
12
Year of publication
2000
Pages
1327 - 1329
Database
ISI
SICI code
1078-8956(200012)6:12<1327:LMT-PP>2.0.ZU;2-F
Abstract
Mycobacterium tuberculosis is a globally successful pathogen due to its abi lity to persist for long periods of time unrecognized by the human immune s ystem. The panoply of genes that allows the organism to enter latency and t hen re-emerge later during endogenous reinfection are now being elucidated. Novel antimicrobials and vaccines will need to target these mycobacterial pathogenic mechanisms to succeed against tuberculosis.