Three ways to make a vesicle

Cargo molecules have to be included in carrier vesicles of different forms and sizes to be transported between organelles. During this process, a limi ted set of proteins, including the coat proteins COPI, COPII and clathrin, carries out a programmed set of sequential interactions that lead to the bu dding of vesicles. A general model to explain the formation of coated vesic les is starting to emerge but the picture is more complex than we had imagi ned.