Secrets of actin-based motility revealed by a bacterial pathogen

Authors
Cameron, LA Giardini, PA Soo, FS Theriot, JA
Citation
La. Cameron et al., Secrets of actin-based motility revealed by a bacterial pathogen, NAT REV MOL, 1(2), 2000, pp. 110-119
Citations number
99
Categorie Soggetti
Cell & Developmental Biology
Journal title
NATURE REVIEWS MOLECULAR CELL BIOLOGY
ISSN journal
14710072 → ACNP
Volume
1
Issue
2
Year of publication
2000
Pages
110 - 119
Database
ISI
SICI code
1471-0072(200011)1:2<110:SOAMRB>2.0.ZU;2-V
Abstract
Actin-based cell motility is a complex process involving a dynamic, self-or ganizing cellular system. Experimental problems initially limited our under standing of this type of motility, but the use of a model system derived fr om a bacterial pathogen has led to a breakthrough. Now, all the molecular c omponents necessary for dynamic actin self-organization and motility have b een identified, setting the stage for future mechanistic studies.