Postsynaptic organization and regulation of excitatory synapses

Citation
Rh. Scannevin et Rl. Huganir, Postsynaptic organization and regulation of excitatory synapses, NAT REV NEU, 1(2), 2000, pp. 133-141
Citations number
118
Categorie Soggetti
Neurosciences & Behavoir
Journal title
NATURE REVIEWS NEUROSCIENCE
ISSN journal
14710048 → ACNP
Volume
1
Issue
2
Year of publication
2000
Pages
133 - 141
Database
ISI
SICI code
1471-0048(200011)1:2<133:POAROE>2.0.ZU;2-Q
Abstract
Dynamic regulation of synaptic efficacy is one of the mechanisms thought to underlie learning and memory. Many of the observed changes in efficacy, su ch as long-term potentiation and long-term depression, result from the func tional alteration of excitatory neurotransmission mediated by postsynaptic glutamate receptors. These changes may result from the modulation of the re ceptors themselves and from regulation of protein networks associated with glutamate receptors. Understanding the interactions in this synaptic comple x will yield invaluable insight into the molecular basis of synaptic functi on. This review focuses on the molecular organization of excitatory synapse s and the processes involved in the dynamic regulation of glutamate recepto rs.