The pathology of REM sleep behavior disorder with comorbid Lewy body dementia

Authors
Turner, RS D'Amato, CJ Chervin, RD Blaivas, M
Citation
Rs. Turner et al., The pathology of REM sleep behavior disorder with comorbid Lewy body dementia, NEUROLOGY, 55(11), 2000, pp. 1730-1732
Citations number
10
Categorie Soggetti
Neurology,"Neurosciences & Behavoir
Journal title
NEUROLOGY
ISSN journal
00283878 → ACNP
Volume
55
Issue
11
Year of publication
2000
Pages
1730 - 1732
Database
ISI
SICI code
0028-3878(200012)55:11<1730:TPORSB>2.0.ZU;2-2
Abstract
A patient with REM sleep behavior disorder who subsequently developed proba ble Lewy body dementia is now reported to have a definite pathologic diagno sis of Lewy body dementia. Examination of brain revealed Lewy bodies as wel l as marked neuronal loss in brainstem monoaminergic nuclei-particularly lo cus coeruleus and substantia nigra-that inhibit cholinergic neurons in the pedunculopontine nucleus mediating atonia during REM sleep.