Improvement of sleep architecture in PD with subthalamic nucleus stimulation

High-frequency stimulation of the subthalamic nucleus (STN) was used to inv estigate the relationship of sleep disorders with motor handicap in PD, In 10 insomniac patients with PD, stimulation reduced nighttime akinesia by 60 % and completely suppressed axial and early morning dystonia, but did not a lleviate periodic leg movements (n = 3) or REM sleep behavior disorders (n = 5), Total sleep time increased by 47%; wakefulness after sleep onset decr eased by 51 minutes. Insomnia in patients with PD may predominantly result from nighttime motor disability.