Patients with intractable epilepsy have low melatonin, which increases following seizures

Citation
Cw. Bazil et al., Patients with intractable epilepsy have low melatonin, which increases following seizures, NEUROLOGY, 55(11), 2000, pp. 1746-1748
Citations number
10
Categorie Soggetti
Neurology,"Neurosciences & Behavoir
Journal title
NEUROLOGY
ISSN journal
00283878 → ACNP
Volume
55
Issue
11
Year of publication
2000
Pages
1746 - 1748
Database
ISI
SICI code
0028-3878(200012)55:11<1746:PWIEHL>2.0.ZU;2-2
Abstract
Melatonin, which is used to treat sleep disorders, has anticonvulsant prope rties. The authors measured salivary melatonin and cortisol, at baseline an d following seizures, in patients with intractable temporal lobe epilepsy a nd controls, Melatonin was reduced in patients with epilepsy at baseline co mpared with controls, and increased threefold following seizures. Cortisol also increased following seizures. Patients with intractable epilepsy have low baseline melatonin levels that increase dramatically following seizures .