Unusual pattern of leukoencephalopathy after morphine sulphate intoxication

We report a 14-year-old girl with an unusual pattern of leukoencephalopathy after intentional intoxication with morphine sulphate tablets. Toxicologic al analysis showed exceedingly high levels of morphine and its metabolites. MRI disclosed a leukoencephalopathy with high signal from the centrum semi ovale, corpus callosum and cerebellar white matter on T2-weighted images. T hese findings could be only partially explained by a hypoxic-ischaemic even t; neurotoxic effects must be considered in this atypical leukoencephalopat hy.