Amiodarone, sotalol, or propafenone in atrial fibrillation: Which is preferred to maintain normal sinus rhythm?

This randomized study compared the efficacy and safety of amiodarone, propa fenone and sotalol in the prevention of atrial fibrillation. Methods: The p opulation consisted of 214 consecutive patients (mean age 64 +/- 8 years, 1 06 men) with recurrent symptomatic atrial fibrillation. After restoration o f sinus rhythm, patients were randomized to amiodarone (200 mg/day), propaf enone (450 mg/day) or sotalol (320 +/- 20 mg/day). Follow-up evaluations we re conducted at 1, 2, 4 and 6 months, and at 3-month intervals thereafter. The proportion of patients developing recurrent atrial fibrillation and/or experiencing unacceptable adverse effects was measured in the three groups by the Kaplan-Meier method. Results: Recurrent atrial fibrillation occurred in 25 of the 75 patients treated with amiodarone compared to 51 of the 75 patients treated with sotalol and 24 of the 64 patients treated with propaf enone. Fourteen patients treated with amiodarone, five with sotalol, and on e with propafenone experienced adverse effects while in sinus rhythm, neces sitating discontinuation of treatment (P < 0.001 for amiodarone and propafe none vs sotalol). The difference between amiodarone and propafenone was sta tistically nonsignificant when all events were included in the analysis. Ho wever, if the analysis wets limit ed to recurrent atrial fibrillation event s, amiodarone was more effective than propafenone (P < 0.05). Conclusions: Amiodarone and propafenone were superior to sotalol in maintaining long-ter m normal sinus rhythm in patients with atrial fibrillation. Amiodarone tend ed to be superior to propafenone, though its long-term efficacy was limited by adverse side effects.