Area under the curve and bioavailability

Authors
Rescigno, A
Citation
A. Rescigno, Area under the curve and bioavailability, PHARMAC RES, 42(6), 2000, pp. 539-540
Citations number
2
Categorie Soggetti
Pharmacology & Toxicology
Journal title
PHARMACOLOGICAL RESEARCH
ISSN journal
10436618 → ACNP
Volume
42
Issue
6
Year of publication
2000
Pages
539 - 540
Database
ISI
SICI code
1043-6618(200012)42:6<539:AUTCAB>2.0.ZU;2-F
Abstract
The Area Under the Curve (AUC) is proportional to the fraction absorbed onl y if the clearance is constant and the concentration uniform; in all other cases the bioavailability cannot be determined by comparing AUCs. (C) 2000 Academic Press.