Transmucosal transport of tobramycin incorporated in SLN after duodenal administration to rats. Part I - A pharmacokinetic study

Tobramycin-loaded solid lipid nanospheres (SLN) were prepared and administe red to rats into the duodenum; their behaviour was compared to that of tobr amycin-loaded SLN administered intravenously (i.v.). A tobramycin control s olution was also administered to rats. Tobramycin in solution is not absorbed by the gastrointestinal route, while tobramycin incorporated in the SLN is absorbed. A high concentration of to bramycin is still present in plasma 24 hours after the duodenal administrat ion of tobramycin-loaded SLN. Tobramycin-loaded SLN administered i.v. showed a prolonged circulation time compared to the i.v. administered tobramycin solution. The AUC of tobramycin in SLN administered duodenally is higher than those o f tobramycin in SLN and in solution administered i.v. (C) 2000 Academic Pre ss.