We discuss different aspects which might influence temperatures deduced fro
m experimental isotopic yields in the multifragmentation process. It is sho
wn that fluctuations due to the finite size of the system and distortions-d
ue to the decay of hot primary fragments conspire to blur the temperature d
etermination in multifragmentation reactions. These facts suggest that calo
ric curves obtained through isotope thermometers, which were taken as evide
nce for a first-order phase transition in nuclear matter, should be investi
gated very carefully.