SUPPRESSING EFFECTS OF HUMAN FETAL CELL EXTRACT ON MICRONUCLEI INDUCED BY CYCLOPHOSPHAMIDE IN MICE

The genotoxicity of human fetal cell extract (HFCE) and its effect on the frequency of micronucleated polychromatic erythrocytes (PCE-MNF) i n mice induced by cyclophosphamide (CP) were studied. Statistically si gnificant differences were not found between the control group and eac h group treated with HFCE (0.3, 3, 30 mg/kg bw). CP (200 mg/kg bw) ind uced a marked increase in MNF (P < 0.01). Administered together with C P, HFCE suppressed the increase of MNF induced by CP. The reduction ef fect is dependent on the dose of HFCE. At doses of 3 and 30 mg/kg bw H FCE, MNF decreased markedly (P < 0.05 and < 0.01, respectively). It sh owed that HFCE did not induce micronucleus formation, while it could s uppress the micronucleus formation induced by CP in mice. The results suggested that HFCE might be antimutagenic and have potential value in clinical application.