Preparation of Re-188-lanreotide peptide and its quality control

Authors
Mushtaq, A Pervez, S Haider, I
Citation
A. Mushtaq et al., Preparation of Re-188-lanreotide peptide and its quality control, RADIOCH ACT, 88(8), 2000, pp. 495-498
Citations number
17
Categorie Soggetti
Inorganic & Nuclear Chemistry
Journal title
RADIOCHIMICA ACTA
ISSN journal
00338230 → ACNP
Volume
88
Issue
8
Year of publication
2000
Pages
495 - 498
Database
ISI
SICI code
0033-8230(2000)88:8<495:PORPAI>2.0.ZU;2-A
Abstract
A simple method is described for the preparation of Re-188-Lanreotide, a ra diolabeled synthetic peptide derived from an analogue of somatostatin, usin g Lanreotide (50 mug) and stannous tartrate to which is added carrier-free Re-188. Th, radiolabeling has been carried out with similar to 555 MBq (15 mCi) with a >95% labeling efficiency and no need for subsequent purificatio n. ITLC and HPLC techniques were employed for monitoring the stability and labeling yield. Radiolabeling results in one major peak when analyzed by re verse-phase (RP) HPLC.