Fludarabin treatment of chronic lymphoid leukemia

Aim. To try effectiveness of fludarabin monotherapy in verified chronic lym phoid leukemia (CLL) in pretreated patients. Material and methods. The treatment effectiveness according to the internat ional criteria of complete and partial remission was assessed in 37 patient s with progressive, splenic, tumor and bone marrow forms of CLL given 5-day courses of fludarabin in a single daily dose 25 mg. Results. In progressive CLL, the remission was achieved in 45% of the patie nts (10% complete and 35% partial), in splenic form - 62.5% (12.5% complete , 50% partial), in tumor form - 50% (100% partial). In bone marrow form no remissions were obtained. Conclusion. Fludarabin is effective in therapy of pretreated CLL patients. The treatment should be adjusted to CLL form.