J. Ohlsson et G. Magnusson, Analogues of glycosphingolipids and glycerolipids suitable for conjugationto gold- and amino-functionalised surfaces, TETRAHEDRON, 56(51), 2000, pp. 9975-9984
A general synthesis of analogues of natural lipids, (i.e. lactosylceramide,
globotriasylceramide, and phosphatidylcholine) where one of the alkyl chai
ns carries a terminal thiol- or carboxyl functionality, is described. The l
ipids were prepared by N- or O-acylation of sphingosine or monoacylglycerol
derivatives. These lipids are suitable for anchoring to gold- or amino-fun
ctionalised surfaces, thus creating mimics of a cell membrane for use in th
e study of protein-carbohydrate interaction. (C) 2000 Elsevier Science Ltd.
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