Analogues of glycosphingolipids and glycerolipids suitable for conjugationto gold- and amino-functionalised surfaces

Citation
J. Ohlsson et G. Magnusson, Analogues of glycosphingolipids and glycerolipids suitable for conjugationto gold- and amino-functionalised surfaces, TETRAHEDRON, 56(51), 2000, pp. 9975-9984
Citations number
28
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON
ISSN journal
00404020 → ACNP
Volume
56
Issue
51
Year of publication
2000
Pages
9975 - 9984
Database
ISI
SICI code
0040-4020(200012)56:51<9975:AOGAGS>2.0.ZU;2-9
Abstract
A general synthesis of analogues of natural lipids, (i.e. lactosylceramide, globotriasylceramide, and phosphatidylcholine) where one of the alkyl chai ns carries a terminal thiol- or carboxyl functionality, is described. The l ipids were prepared by N- or O-acylation of sphingosine or monoacylglycerol derivatives. These lipids are suitable for anchoring to gold- or amino-fun ctionalised surfaces, thus creating mimics of a cell membrane for use in th e study of protein-carbohydrate interaction. (C) 2000 Elsevier Science Ltd. All rights reserved.