Structure elucidation of fumagillin-related natural products

Authors
Halasz, J Podanyi, B Vasvari-Debreczy, L Szabo, A Hajdu, F Bocskei, Z Hegedus-Vajda, J Gyorbiro, A Hermecz, I
Citation
J. Halasz et al., Structure elucidation of fumagillin-related natural products, TETRAHEDRON, 56(51), 2000, pp. 10081-10085
Citations number
26
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON
ISSN journal
00404020 → ACNP
Volume
56
Issue
51
Year of publication
2000
Pages
10081 - 10085
Database
ISI
SICI code
0040-4020(200012)56:51<10081:SEOFNP>2.0.ZU;2-U
Abstract
Fumagillin is currently the only means of treatment of microsporidiosis, wh ich is frequent and fatal in AIDS patients. Results relating to NMR and X-r ay crystallographic studies of fumagillin and the structure elucidation of three related compounds are reported. In the main impurity of fumagillin th ere is an exocyclic double bond instead of the spiroepoxide moiety. The sol id-state and solution structures of fumagillin were compared with the confo rmation of fumagillin complexed to aminopeptidase-2. (C) 2000 Elsevier Scie nce Ltd. All rights reserved.