A rapid stereoselective access to highly substituted piperidines

Authors
Glasson, SR Canet, JL Troin, Y
Citation
Sr. Glasson et al., A rapid stereoselective access to highly substituted piperidines, TETRAHEDR L, 41(50), 2000, pp. 9797-9802
Citations number
11
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
41
Issue
50
Year of publication
2000
Pages
9797 - 9802
Database
ISI
SICI code
0040-4039(200012)41:50<9797:ARSATH>2.0.ZU;2-1
Abstract
An intramolecular Mannich reaction, involving various achiral aldehydes tog ether with an alpha -chiral amine is employed as the key step for a stereoc ontrolled synthesis of highly substituted piperidine systems. Accordingly, 12 new piperidines bearing four asymmetric centers were prepared in six ste ps from commercial ketones. (C) 2000 Published by Elsevier Science Ltd.