The synthesis of tamandarin B is described. Key steps in the synthesis of t
he macrocycle component include a diastereoselective ketone reduction, line
ar precursor formation via an activated pentafluorophenyl ester, and HATU-p
romoted cyclization. Side-chain coupling was achieved in excellent yield wi
th the newly developed coupling reagent DEPBT. (C) 2000 Published by Elsevi
er Science Ltd.