In pursuit of an anticancer vaccine: a monomolecular construct containing multiple carbohydrate antigens

Authors
Williams, LJ Harris, CR Glunz, PW Danishefsky, SJ
Citation
Lj. Williams et al., In pursuit of an anticancer vaccine: a monomolecular construct containing multiple carbohydrate antigens, TETRAHEDR L, 41(49), 2000, pp. 9505-9508
Citations number
10
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
41
Issue
49
Year of publication
2000
Pages
9505 - 9508
Database
ISI
SICI code
0040-4039(200012)41:49<9505:IPOAAV>2.0.ZU;2-M
Abstract
The synthesis of a new type of anti-cancer vaccine candidate is presented. This compound contains the TF, Le(y), and Tn tumor antigens clustered in a monomolecular array. In addition to being a realistic mimic of 'micro-heter ogeneous' mucins, this class of vaccine may trigger a multifaceted immune r esponse convergent on a particular cancer type. (C) 2000 Elsevier Science L td. All rights reserved.