Enantioselective syntheses of carbocyclic ribavirin and its analogs: linear versus convergent approaches

Authors
Kuang, RZ Ganguly, AK Chan, TM Pramanik, BN Blythin, DJ McPhail, AT Saksena, AK
Citation
Rz. Kuang et al., Enantioselective syntheses of carbocyclic ribavirin and its analogs: linear versus convergent approaches, TETRAHEDR L, 41(49), 2000, pp. 9575-9579
Citations number
16
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
41
Issue
49
Year of publication
2000
Pages
9575 - 9579
Database
ISI
SICI code
0040-4039(200012)41:49<9575:ESOCRA>2.0.ZU;2-#
Abstract
The first enantioselective syntheses of carbocyclic ribavirin by both conve rgent and linear approaches are described. The linear approach from chiral nonracemic 2-azabicyclo[2.2.1]hept-5-en-3-one proves to be a highly efficie nt route to carbocyclic analogs of ribavirin. (C) 2000 Elsevier Science Ltd . All rights reserved.