An amino acid that controls polypeptide helicity: beta-amino alanine, the first strongly stabilizing C-terminal helix stop signal

Authors
Deechongkit, S Kennedy, RJ Tsang, KY Renold, P Kemp, DS
Citation
S. Deechongkit et al., An amino acid that controls polypeptide helicity: beta-amino alanine, the first strongly stabilizing C-terminal helix stop signal, TETRAHEDR L, 41(49), 2000, pp. 9679-9683
Citations number
16
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON LETTERS
ISSN journal
00404039 → ACNP
Volume
41
Issue
49
Year of publication
2000
Pages
9679 - 9683
Database
ISI
SICI code
0040-4039(200012)41:49<9679:AAATCP>2.0.ZU;2-M
Abstract
beta -Amino alanine is shown to stop helix propagation in a polyalanine con text while effectively stabilizing the resulting C-terminus. Structural evi dence is provided by circular dichroism and t/c ratios from the reporting c onformational template Ac-Hel. (C) 2000 Elsevier Science Ltd. All rights re served.