An asymmetric synthesis of the novel H-3 agonist (+)-(3R,4R)-3-(4-imidazolyl)-4-methylpyrrolidine dihydrochloride (Sch 50971)

Authors
Aslanian, R Lee, G Iyer, RV Shih, NY Piwinski, JJ Draper, RW McPhail, AT
Citation
R. Aslanian et al., An asymmetric synthesis of the novel H-3 agonist (+)-(3R,4R)-3-(4-imidazolyl)-4-methylpyrrolidine dihydrochloride (Sch 50971), TETRAHEDR-A, 11(19), 2000, pp. 3867-3871
Citations number
15
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON-ASYMMETRY
ISSN journal
09574166 → ACNP
Volume
11
Issue
19
Year of publication
2000
Pages
3867 - 3871
Database
ISI
SICI code
0957-4166(20001006)11:19<3867:AASOTN>2.0.ZU;2-A
Abstract
A short, high yielding, enantioselective synthesis of the novel H-3 agonist Sch 50971 1 is described. The key enantiodifferentiating step is the 1,4-a ddition of a chiral N-propionyloxazolidinone to a nitroolefin. (C) 2000 Els evier Science Ltd. All rights reserved.