A national confidential enquiry into community acquired pneumonia deaths in young adults in England and Wales

Background-The aim of this study was to describe the frequency, causal path ogens, management, and outcome of a population of young adults who died fro m community acquired pneumonia (CAP). Methods-Pneumonia deaths in England and Wales in adults aged 15-44 were ide ntified between September 1995 and August 1996. Patients with underlying ch ronic illness including HIV infection were excluded. Clinical details for e ach case were collected from the hospital and general practitioner records. Results-Death from CAP was identified in 27 previously well young adults (1 .2 per million population per year). Twenty were known to have consulted a GP for this illness. Nine received antibiotics before hospital admission. A causative pathogen was identified in 17 cases (Streptococcus pneumoniae in eight). Bacteraemia was present in seven. All patients who reached a hospi tal ward received antibiotics (69% within two hours of admission). The Brit ish Thoracic Society antibiotic guidelines for severe CAF were followed in only 10 cases. Cardiac arrest at home or on arrival at hospital occurred in six cases, one of whom was successfully resuscitated. Of the remaining 21 patients, 71% had two or more markers of severe CAP. All 22 who were admitt ed reached an intensive care unit, but 11 of these required transfer to ano ther hospital for some aspect of intensive care. One third of patients died within 24 hours of presenting to the hospital. Conclusions-Death from CAP in previously fit young adults still occurs. Whi le some deaths might be preventable by management, most are unlikely to be preventable by current management practices.